Variegated RHOA mutations in adult T-cell leukemia/lymphoma

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Variegated RHOA mutations in adult T-cell leukemia/lymphoma.

Adult T-cell leukemia/lymphoma (ATLL) is a distinct form of peripheral T-cell lymphoma with poor prognosis, which is caused by the human T-lymphotropic virus type 1 (HTLV-1). In contrast to the unequivocal importance of HTLV-1 infection in the pathogenesis of ATLL, the role of acquired mutations in HTLV-1 infected T cells has not been fully elucidated, with a handful of genes known to be recurr...

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ژورنال

عنوان ژورنال: Blood

سال: 2016

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood-2015-06-644948